KMID : 0368820130520020067
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Journal of the Korean Neuropsychiatr Association 2013 Volume.52 No. 2 p.67 ~ p.75
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Korean Addiction Treatment Guidelines Series (II): Pharmacological Treatment of Alcohol Withdrawal
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Kim Hee-Yeon
Lee Hae-Kook Lee Kye-Seong Joe Keun-Ho Choi Sam-Wook Seo Jeong-Seok
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Abstract
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Objectives: In development of Korean addiction treatment guidelines, the aim of this study was to investigate the experts¡¯ consensus regarding current pharmacological practice in treatment of alcohol withdrawal.
Methods: Using recommendations from foreign clinical guidelines, which were either lacking in evidence or could not be directly applied to Korea, the executive committee developed a questionnaire consisting of 17 questions. Using a nine-point scale, members of the Korean Addiction Psychiatry, who were experts (n=150) with sufficient experience in treatment of alcohol use disorder, were asked to evaluate the appropriateness of each item on the questionnaire. We classified the experts¡¯ opinion according to three categories, based on the lowest scores of 6.5 or greater as a first-line/preferred treatment, 3.5-6.5 as a second-line/reasonable treatment, and lower than 3.5 as a third-line/inappropriate treatment. The consensus was determined by chi-square test (p<0.05). Response rate was 70.4% (81/115).
Results: The results of the survey from the experts were as follows: 1) Symptom triggered therapy (STT) was the most appropriate strategy in treatment of alcohol withdrawal (95% CI 7.41-8.04). 2) Prophylactic benzodiazepine was recommended for management of expecting alcohol withdrawal in out-patient-department patients. 3) Among benzodiazepines, lorazepam was the most preferred. 4) For patients with severe withdrawal, lorazepam 7.4 mg/day (95% CI 6.48-8.25, maximum dose=20 mg) was recommended. 5) Risperidone, quetiapine, and haloperidol were the first-line drugs for patients with alcohol withdrawal and combined psychotic symptoms. 6) 127.5 mg (95% CI 111-145) for 2.8 months of prophylactic thiamine and 213.5 mg (95% CI 190-240) for 6.2 months of thiamine for Wernicke-Korsakoff¡¯s syndrome were recommended.
Conclusion: We hope that these Korean addiction treatment guidelines, added by the Korean experts¡¯ consensus, will be helpful in promoting the efficacy of treatment for alcohol withdrawal.
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KEYWORD
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Addiction, Guidelines, Alcohol withdrawal, Benzodiazepine, Symptom triggered therapy, Thiamine
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